Prevalence of Enterococcus species in adults with periodontal health or with periodontitis: a systematic review.

The aim of this study was to evaluate the prevalence of Enterococcus species in the mouth of adults with periodontal health and periodontitis. A systematic search was made in databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The search for articles was conducted in Medline/PubMed, Latin American and Caribbean Health Sciences Literature Database (LILACS), Cochrane Library, Scopus, Embase, Web of Science databases and in the System of Information on Grey Literature in Europe (SINGLE) and included articles published in English up to April 25th, 2021. Observational studies in humans with and without periodontitis were evaluated to identify the prevalence of Enterococcus species. Articles that met the inclusion criteria were analyzed and classified to determine the quality rating in good, fair, and poor. A new detailed checklist for quality assessment was developed based on the information required for applicable data extraction in reviews. The study design, sample size, demographic data, periodontal clinical parameters, microbial analysis method, biological sample, prevalence of Enterococcus spp., and correlations with periodontal clinical parameters were assessed. After screening and full-text reading, 8 articles met the inclusion criteria. All selected studies showed a significantly higher prevalence of Enterococcus spp. in patients with periodontitis compared with periodontally healthy patients. Thus, the present systematic review suggests that the prevalence of Enterococcus faecalis in the mouth of periodontitis individuals is higher than that of periodontally healthy individuals.

Prevalence of Enterococcus species in adults with periodontal health or with periodontitis: a systematic review

Abstract The aim of this study was to evaluate the prevalence of Enterococcus species in the mouth of adults with periodontal health and periodontitis. A systematic search was made in databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The search for articles was conducted in Medline/PubMed, Latin American and Caribbean Health Sciences Literature Database (LILACS), Cochrane Library, Scopus, Embase, Web of Science databases and in the System of Information on Grey Literature in Europe (SINGLE) and included articles published in English up to April 25th, 2021. Observational studies in humans with and without periodontitis were evaluated to identify the prevalence of Enterococcus species. Articles that met the inclusion criteria were analyzed and classified to determine the quality rating in good, fair, and poor. A new detailed checklist for quality assessment was developed based on the information required for applicable data extraction in reviews. The study design, sample size, demographic data, periodontal clinical parameters, microbial analysis method, biological sample, prevalence of Enterococcus spp., and correlations with periodontal clinical parameters were assessed. After screening and full-text reading, 8 articles met the inclusion criteria. All selected studies showed a significantly higher prevalence of Enterococcus spp. in patients with periodontitis compared with periodontally healthy patients. Thus, the present systematic review suggests that the prevalence of Enterococcus faecalis in the mouth of periodontitis individuals is higher than that of periodontally healthy individuals.

Análise da associação entre a periodontite e polimorfismos de nucleotídeo único da interleucina-1beta / Analysis of the association between periodontitis and interleukin-1beta single nucleotide polymorphisms

A periodontite é uma doença inflamatória, que pode ser classificada em Periodontite Crônica (PC) ou Periodontite Agressiva (PA), desencadeada por um desequilíbrio na microbiota subgengival, que pode ser influenciado por diversos fatores, como polimorfismos genéticos. Dessa forma, o objetivo deste trabalho foi analisar, através de uma revisão da literatura, se há ou não associação entre a periodontite e polimorfismos genéticos de nucleotídeo único (SNPs). Os genes IL1B +3954(3), -511, -31 foram os alvos desta pesquisa, por serem os mais estudados e apresentarem boa plausibilidade biológica. Foi realizada uma busca no PubMed e ao final 24 artigos de estudos casos-controle foram selecionados. Na maioria dos estudos não foi encontrada associação positiva entre os SNPs +3954(3), -511, -31 da IL1B e a PA ou PC. Dessa forma, é possível concluir que não há associação positiva entre a periodontite e os SNPs IL1B +3954(3), -511, -31 e PA e PC. Todavia os resultados devem ser analisados com cautela, pois os estudos apresentam limitações. (AU)

Periodontitis is an inflammatory disease which is classified as chronic periodontitis (PC) or aggressive periodontitis (PA) and is initiated by an unbalance in subgengival microbiota which for their part can be influenced by a lot of factors, such as genetic polymorphism. Therefore, the aim of this study was to analyse if there is an association between periodontitis and single nucleotide polymorphisms (SNPs). The genes IL1B +3954(3), -511, -31 were chosen as the targets of this literature review, because they have good biologic plausibility and are the most studied in literature. A search was conducted on PubMed and the results analysed and 24 case-controls articles were chosen.Most of the studies did not find a positive association between the ILB1 SNPs +3954(3), -511, -31 and PA e PC. Therefore, the case-controls studies indicated that there is no positive association between SNPs IL1B +3954(3), -511, -31 and PA or PC. However, the results of this work must be analysed carefully as the studies used have limitations. (AU)